Article
Two substitutions at the same position in the mitochondrial cytochrome b gene of S. cerevisiae induce a mitochondrial myxothiazol resistance and impair the respiratory growth of the mutated strains abbeit maintaining a good electron transfer activity.
Current genetics - 1 Dec 1990
Tron T, Lemesle-Meunier D
Abstract excerpt
Two cytochrome b respiratory-deficient mutants were sequenced and their DNA base change identified, leading to the replacement of glycine (G137 by valine or glutamic acid. No variation in their cytochrome b content with regard to cytochrome oxidase and cytochrome (c + c1) was found to have occurr...
Topics
- Amino Acid Sequence
- Cytochrome b Group
- Drug Resistance, Microbial
- Electron Transport
- Genes, Fungal
- Methacrylates
- Mitochondria
- Molecular Sequence Data
- Mutation
- Oxygen Consumption
- Protein Conformation
- Saccharomyces cerevisiae
- Thiazoles