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Article

Antimycin resistance and ubiquinol cytochrome c reductase instability associated with a human cytochrome b mutation.

Biochimica et biophysica acta - 16 Dec 1996

Bouzidi M F, Carrier H, Godinot C

Abstract excerpt

Progressive exercise intolerance was associated with a decreased maximal rate of ubiquinol cytochrome c reductase (complex III) activity in the muscle mitochondria of the studied patient and with a thirty five-fold increase in the I50 for antimycin A. In contrast, myxothiazol sensitivity was not altered. Complex III activity was stable at 37 degrees C, but progressively decreased at 4 degrees C. An heteroplasmic...

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Identifiers

PMID: 8988236
DOI: 10.1016/s0925-4439(96)00055-5

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