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Neuregulin 1-mediated ErbB2/ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation

1 Jan 2015

Abstract excerpt

During placentation, foetal trophoblasts invade deeply into maternal tissue to establish a foeto-maternal circulation. We have previously shown that extravillous trophoblast (EVT) lineage cells express ErbB2 and ErbB3, of which the potential as an oncogenic unit is well established. However, a physiological function of this receptor combination in humans remains a puzzling question. Here, we demonstrate...

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PMID: 26490994
DOI: 10.1242/jcs.176933

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