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Article

Evidence for plasticity genotypes in a gene-gene-environment interaction: the TRAILS study.

Genes, brain, and behavior - 1 Nov 2010

Nederhof E, Bouma E M C, Riese H, Laceulle O M, Ormel J, Oldehinkel A J

Abstract excerpt

The purpose was to study how functional polymorphisms in the brain derived neurotrophic factor gene (BDNF val66met) and the serotonin transporter gene linked promotor region (5-HTTLPR) interact with childhood adversities in predicting Effortful Control. Effortful Control refers to the ability to regulate behavior in a goal-directed manner and is an interesting endophenotype for psychopathology because of its...

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Source

Identifiers

PMID: 20738408
DOI: 10.1111/j.1601-183X.2010.00637.x

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Evidence for plasticity genotypes in a gene-gene-environment interaction: the TRAILS study.PMID 20738408Read ↗

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Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.Semantic proximity Read ↗

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