Article
Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription.
Cancer research - 1 Oct 2010
Buggins Andrea G S, Pepper Chris, Patten Piers E M, Hewamana Saman, Gohil Satyen, Moorhead Jane, Folarin Najeem'deen, Yallop Deborah, Thomas N Shaun B, Mufti Ghulam J, Fegan Chris, Devereux Stephen
Abstract excerpt
Chronic lymphocytic leukemia (CLL) cells rapidly undergo apoptosis in vitro, suggesting that the in vivo microenvironment provides crucial antiapoptotic signals. Overexpression of the antiapoptotic proteins Bcl-2 and Mcl-1 is a hallmark of CLL, and their expression is further enhanced in the lymphoid tissues. However, the high levels of Mcl-1 found in peripheral blood samples, coupled with its short half-life,...
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