Article

MYCN Directly Targets NeuroD1 to Promote Cellular Proliferation in Neuroblastoma

2021-12-23

Abstract excerpt

NeuroD1 is a neuronal differentiation factor that contains a basic helixloophelix (bHLH) motif. Recently, NeuroD1 was found to be associated with tumorigenesis in neuroblastoma (NB) and is known to promote cell proliferation and migration in these cells. Here we found that MYCN regulates the expression of NeuroD1 in NB cells and that the downregulation of MYCN using short hairpin RNAs (shRNA) results in the inhibi...

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Literature Corpus work: 92662184-55da-5e7b-bb8e-3a16599de090
DOI: 10.3727/096504021x16401852341873

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