Article
Improved motor function in dko mice by intravenous transplantation of bone marrow-derived mesenchymal stromal cells.
Cytotherapy - 1 Jan 2011
Li Zhong, Liu Hong-Ying, Lei Qing-Feng, Zhang Cheng, Li Shu-Nong
Abstract excerpt
BACKGROUND AIMS: We explored the potential therapeutic value of transplanting bone marrow (BM)-derived mesenchymal stromal cells (MSC) into utrophin/dystrophin-deficient double knock-out (dko) mice, a murine model of Duchenne muscular dystrophy. METHODS: MSC from male rats were isolated and transplanted into female dko mice via the caudal vein. Behavior and locomotor function were later evaluated, along with the...
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