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Article

Bone marrow transplantation attenuates the myopathic phenotype of a muscular mouse model of spinal muscular atrophy.

Stem cells (Dayton, Ohio) - 1 Dec 2006

Salah-Mohellibi Nouzha, Millet Gaelle, André-Schmutz Isabelle, Desforges Bénédicte, Olaso Robert, Roblot Natacha, Courageot Sabrina, Bensimon Gilbert, Cavazzana-Calvo Marina, Melki Judith

Abstract excerpt

Bone marrow (BM) transplantation was performed on a muscular mouse model of spinal muscular atrophy that had been created by mutating the survival of motor neuron gene (Smn) in myofibers only. This model is characterized by a severe myopathy and progressive loss of muscle fibers leading to paralysis. Transplantation of wild-type BM cells following irradiation at a low dose (6 Gy) improved motor capacity (+85%)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16888281
DOI: 10.1634/stemcells.2006-0170

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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