Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TAT-μUtrophin mitigates the pathophysiology of dystrophin and utrophin double-knockout mice.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jul 2011

Call Jarrod A, Ervasti James M, Lowe Dawn A

Abstract excerpt

Previously, we demonstrated functional substitution of dystrophin by TAT-μUtrophin (TAT-μUtr) in dystrophin-deficient mdx mice. Herein, we addressed whether TAT-μUtr could improve the phenotype of dystrophin and utrophin double-knockout (mdx:utr(-/-)) mice. Specifically, we quantitatively compared survival and quality of life assessments in mdx:utr(-/-) mice receiving TAT-μUtr protein administration against...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dystrophin
Share to Eating
Share to Feeding Behavior

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred mdx

Share to Muscle Contraction

Share to Muscle Strength

Share to Muscular Dystrophy, Duchenne

Share to Utrophin

Source

Open in PubMed Open full text

Identifiers

PMID: 21565990
DOI: 10.1152/japplphysiol.00248.2011
PMCID: PMC3137527

Genes

TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TAT-μUtrophin mitigates the pathophysiology of dystrophin and utrophin double-knockout mice.PMID 21565990Read ↗

Functional Substitution by TAT-Utrophin in Dystrophin-Deficient MiceSemantic proximity Read ↗

Micro-utrophin Improves Cardiac and Skeletal Muscle Function of Severely Affected D2/mdx MiceSemantic proximity Read ↗

The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophySemantic proximity Read ↗

Low dystrophin levels increase survival and improve muscle pathology and function in dystrophin/utrophin double-knockout mice.Semantic proximity Read ↗

Adenovirus-mediated utrophin gene transfer mitigates the dystrophic phenotype of mdx mouse muscles.Semantic proximity Read ↗

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitorsSemantic proximity Read ↗

Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery.Semantic proximity Read ↗

Long-Term Treatment of Tamoxifen and Raloxifene Alleviates Dystrophic Phenotype and Enhances Muscle Functions of FKRP Dystroglycanopathy.Semantic proximity Read ↗

Improved motor function in dko mice by intravenous transplantation of bone marrow-derived mesenchymal stromal cells.Semantic proximity Read ↗

Novel adeno-associated viral vector delivering the utrophin gene regulator jazz counteracts dystrophic pathology in mdx mice.Semantic proximity Read ↗

Heregulin ameliorates the dystrophic phenotype in mdx mice.Semantic proximity Read ↗

Micro-dystrophin and follistatin co-delivery restores muscle function in aged DMD modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.