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Article

HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta.

PloS one - 13 Aug 2010

Hall Caroline H T, Kassel Rachel, Tacke Robert S, Hahn Young S

Abstract excerpt

BACKGROUND: Hepatitis C Virus (HCV) is remarkably efficient at establishing persistent infection and is associated with the development of chronic liver disease. Impaired T cell responses facilitate and maintain persistent HCV infection. Importantly, CD4(+) regulatory T cells (Tregs) act by dampening antiviral T cell responses in HCV infection. The mechanism for induction and/or expansion of Tregs in HCV is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20730048
DOI: 10.1371/journal.pone.0012154
PMCID: PMC2921368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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