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Article

Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus

2 Oct 2015

Abstract excerpt

The human insulin receptor (IR) exists in two isoforms that differ by the absence (IR-A) or the presence (IR-B) of a 12-amino acid segment encoded by exon 11. Both isoforms are functionally distinct regarding their binding affinities and intracellular signalling. However, the underlying mechanisms related to their cellular functions in several tissues are only partially understood. In this review, we summarize...

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PMID: 26431063
DOI: 10.1002/dmrr.2729

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