Viability of clathrin heavy-chain-deficient Saccharomyces cerevisiae is compromised by mutations at numerous loci: implications for the suppression hypothesis.

doi:10.1128/mcb.11.8.3868-3878.1991

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Article

Viability of clathrin heavy-chain-deficient Saccharomyces cerevisiae is compromised by mutations at numerous loci: implications for the suppression hypothesis.

Molecular and cellular biology - 1 Aug 1991

Munn A L, Silveira L, Elgort M, Payne G S

Abstract excerpt

The gene encoding clathrin heavy chain in Saccharomyces cerevisiae (CHC1) is not essential for growth in most laboratory strains tested. However, in certain genetic backgrounds, a deletion of CHC1 (chc1) results in cell death. Lethality in these chc1 strains is determined by a locus designated SCD1 (suppressor of clathrin deficiency) which is unlinked to CHC1 (S. K. Lemmon and E. W. Jones, Science 238:504-509,...

Topics

Chromosome Deletion
Clathrin
DNA, Fungal
Diploidy
Ethyl Methanesulfonate
Genes, Fungal
Genes, Lethal
Genotype
Heterozygote
Kinetics
Macromolecular Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Plasmids

Restriction Mapping

Saccharomyces cerevisiae

Spores, Fungal

Suppression, Genetic

Source

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Identifiers

PMID: 2072897
DOI: 10.1128/mcb.11.8.3868-3878.1991
PMCID: PMC361173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2072897-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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