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Article

Viability of clathrin heavy-chain-deficient Saccharomyces cerevisiae is compromised by mutations at numerous loci: implications for the suppression hypothesis.

Molecular and cellular biology - 1 Aug 1991

Munn A L, Silveira L, Elgort M, Payne G S

Abstract excerpt

The gene encoding clathrin heavy chain in Saccharomyces cerevisiae (CHC1) is not essential for growth in most laboratory strains tested. However, in certain genetic backgrounds, a deletion of CHC1 (chc1) results in cell death. Lethality in these chc1 strains is determined by a locus designated SCD1 (suppressor of clathrin deficiency) which is unlinked to CHC1 (S. K. Lemmon and E. W. Jones, Science 238:504-509,...

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Identifiers

PMID: 2072897
DOI: 10.1128/mcb.11.8.3868-3878.1991
PMCID: PMC361173

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