Article
Analysis of genetic variations in the RGS9 gene and antipsychotic-induced tardive dyskinesia in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2009
Liou Ying-Jay, Chen Mao-Liang, Wang Ying-Chieh, Chen Jen-Yeu, Liao Ding-Lieh, Bai Ya-Mei, Lin Chao-Cheng, Chen Tzu-Ting, Mo Geng-Han, Lai I-Ching
Abstract excerpt
Some patients treated chronically with antipsychotics develop tardive dyskinesia (TD), an abnormal involuntary movement disorder. Typical antipsychotics block D(2) dopamine receptors (D(2)DR) and produce D(2)DR supersensitivity. On contrary, regulators of G-protein signaling (RGS) can enhance the...
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