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SERPINB1 promotes Senecavirus A replication by degrading IKBKE and regulating the IFN pathway via autophagy

9 Oct 2023

Abstract excerpt

ABSTRACT Innate immunity and autophagy play crucial roles in regulating Senecavirus A (SVA) replication. However, the reciprocal coordination between these systems during virus infection is not understood. Our results show that SERPINB1, a member of the SERPINB family, facilitates SVA replication. Mechanistically, ectopic expression of SERPINB1 increases the degradation of IκB kinase epsilon (IKBKE) through the...

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PMID: 37811994
DOI: 10.1128/jvi.01045-23

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