Article
Mendelian susceptibility to mycobacterial disease.
Clinical genetics - 1 Jan 2011
Cottle L E
Abstract excerpt
The host response to mycobacterial infection is mediated by the type I cytokine pathway (cell-mediated immunity). Deficiencies in this response result in susceptibility to poorly pathogenic mycobacterial species such as bacille Calmette-Guérin and environmental mycobacteria. In recent years a number of mutations in the genes encoding major components in the type I cytokine axis have been described which...
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