Mendelian susceptibility to mycobacterial infection in man.

doi:10.1016/s0952-7915(98)80114-3

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Article

Mendelian susceptibility to mycobacterial infection in man.

Current opinion in immunology - 1 Aug 1998

Altare F, Jouanguy E, Lamhamedi S, Döffinger R, Fischer A, Casanova J L

Abstract excerpt

Selective susceptibility to poorly pathogenic mycobacteria, such as bacille Calmette-Guérin vaccine and environmental non-tuberculous mycobacteria, has long been suspected to be a mendelian disorder but its molecular basis has remained elusive. Recently, recessive mutations in the interferon-gamm...

Topics

Genetic Predisposition to Disease
Humans
Interferon-gamma
Interleukin-12
Mycobacterium Infections
Receptors, Interleukin
Receptors, Interleukin-12

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