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Article

Germ-line mutation of NKX3.1 cosegregates with hereditary prostate cancer and alters the homeodomain structure and function.

Cancer research - 1 Jan 2006

Zheng S Lilly, Ju Jeong-ho, Chang Bao-li, Ortner Elizabeth, Sun Jielin, Isaacs Sarah D, Sun Jishang, Wiley Kathy E, Liu Wennuan, Zemedkun Micheas, Walsh Patrick C, Ferretti James, Gruschus James, Isaacs William B, Gelmann Edward P, Xu Jianfeng

Abstract excerpt

NKX3.1, a gene mapped to 8p21, is a member of the NK class of homeodomain proteins and is expressed primarily in the prostate. NKX3.1 exerts a growth-suppressive and differentiating effect on prostate epithelial cells. Because of its known functions and its location within a chromosomal region where evidence for prostate cancer linkage and somatic loss of heterozygosity is found, we hypothesize that sequence...

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Share to Chromosome Segregation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16397218
DOI: 10.1158/0008-5472.CAN-05-1550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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