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Article

Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes.

Immunology letters - 30 Nov 2010

Boselli Daniela, Ragimbeau Josiane, Orlando Luca, Cappello Paola, Capello Michela, Ambrogio Chiara, Chiarle Roberto, Marsili Giulia, Battistini Angela, Giovarelli Mirella, Pellegrini Sandra, Novelli Francesco

Abstract excerpt

In T lymphocytes, the internalization of the R2 chain of the IFN-γ receptor (IFN-γR2) prevents the switching-on of pro-apoptotic and anti-proliferative genes induced by the IFN-γ/STAT1 pathway. In fibroblasts, a critical role of controlling the IFN-γR2 internalization is played by the LI(255-256)...

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Identifiers

PMID: 20709103
DOI: 10.1016/j.imlet.2010.08.005

Genes

STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20709103-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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