Article
Association of matrix metalloproteinase-1 gene polymorphism with glioblastoma multiforme in a northern Indian population.
Journal of neuro-oncology - 1 May 2011
Malik Nitin, Kumar Raj, Prasad Kashi N, Kawal Priyanka, Srivastava Arun, Mahapatra Ashok K
Abstract excerpt
Matrix metalloproteinase-1 (MMP-1) is known to be involved in the pathogenesis of glioma. It damages the extra-cellular matrix to produce invasiveness in cancer tissue, and hence has a direct effect in cancer invasion. The study aims to explore the association of single nucleotide polymorphism of -1607 MMP-1 gene with susceptibility to glioblastoma multiforme (GBM) in northern Indian subjects. One hundred and ten...
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