Article
Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China.
Journal of neuro-oncology - 1 Oct 2007
Lu Zhongqiang, Cao Yanyan, Wang Yimin, Zhang Qingjun, Zhang Xianghong, Wang Shuheng, Li Yuehong, Xie Huiling, Jiao Baohua, Zhang Jianhui
Abstract excerpt
The single nucleotide polymorphisms (SNPs) in the promoter region of matrix metalloproteinase (MMP) genes may influence tumor occurrence and progression via modifying mRNA transcription and protein expression. The study aims to explore the association of the SNPs in MMP-1, 3 and MMP-9 promoters with susceptibility to adult brain astrocytoma in northern China. Genotyping for the MMP-1 -1607 2G/1G, MMP-3 -1171...
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