Article
Functional polymorphism of the MMP-1 promoter (-1607 1G/2G) in potentially malignant and malignant head and neck lesions in an Indian population.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Dec 2010
Chaudhary Ajay Kumar, Pandya Shruti, Mehrotra Ravi, Bharti Alok C, Jain Sachin, Singh Mamta
Abstract excerpt
Matrix metalloproteinases (MMP) are a family of zinc-dependent proteases that degrade the entire component of the extracellular matrix. Our study explores the association of the MMP1 gene promoter (-1607 1G/2G) polymorphisms in oral submucous fibrosis (OSMF) and head and neck squamous cell carcinoma (HNSCC) in an Indian population. The MMP1 single-nucleotide polymorphism (SNP) was genotyped by polymerase chain...
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