The role of genetic variation near interferon-kappa in systemic lupus erythematosus.

doi:10.1155/2010/706825

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Article

The role of genetic variation near interferon-kappa in systemic lupus erythematosus.

Journal of biomedicine & biotechnology - 1 Jan 2010

Harley Isaac T W, Niewold Timothy B, Stormont Rebecca M, Kaufman Kenneth M, Glenn Stuart B, Franek Beverly S, Kelly Jennifer A, Kilpatrick Jeffrey R, Hutchings David, Divers Jasmin, Bruner Gail R, Edberg Jeffrey C, McGwin Gerald, Petri Michelle A, Ramsey-Goldman Rosalind, Reveille John D, Vilá-Pérez Luis M, Merrill Joan T, Gilkeson Gary S, Vyse Timothy J, Alarcón-Riquelme Marta E, Cho Soo-Kyung, Jacob Chaim O, Alarcón Graciela S, Moser Kathy L, Gaffney Patrick M, Kimberly Robert P, Bae Sang-Cheol, Langefeld Carl D, Harley John B, Guthridge Joel M, James Judith A

Abstract excerpt

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by increased type I interferons (IFNs) and multiorgan inflammation frequently targeting the skin. IFN-kappa is a type I IFN expressed in skin. A pooled genome-wide scan implicated the IFNK locus in SLE susceptibility. We studied IFNK single nucleotide polymorphisms (SNPs) in 3982 SLE cases and 4275 controls, composed of European...

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Identifiers

PMID: 20706608
DOI: 10.1155/2010/706825
PMCID: PMC2914299

Genes

IFNK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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