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Article

The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids.

The international journal of neuropsychopharmacology - 1 Jun 2011

Boucher Aurélie A, Hunt Glenn E, Micheau Jacques, Huang Xufeng, McGregor Iain S, Karl Tim, Arnold Jonathon C

Abstract excerpt

Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with the synthetic analogue of Δ9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We measured the impact...

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Source

Identifiers

PMID: 20701826
DOI: 10.1017/S146114571000091X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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