Article
CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells.
Molecular vision - 1 Jan 2012
Peng Mei-Ling, Tsai Yi-Yu, Chiang Chun-Chi, Huang Ying-Che, Chou Ming-Chih, Yeh Kun-Tu, Lee Huei, Cheng Ya-Wen
Abstract excerpt
BACKGROUND: A thymine/cytosine point mutation in the MSP I restriction site of cytochrome P450 1A1 (CYP1A1) has been linked to susceptibility to smoking-related cancers and is reported to result in increased enzyme activity. Therefore, we sought to determine whether allelic variation of CYP1A1 is associated with protein expression and protein activity in pterygium. METHODS: We collected 150 pterygium samples and...
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