Article
Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat.
The Journal of cell biology - 9 Aug 2010
Whittle James R R, Schwartz Thomas U
Abstract excerpt
Ancestral coatomer element 1 (ACE1) proteins assemble latticework coats for COPII vesicles and the nuclear pore complex. The ACE1 protein Sec31 and Sec13 make a 2:2 tetramer that forms the edge element of the COPII outer coat. In this study, we report that the COPII accessory protein Sec16 also contains an ACE1. The 165-kD crystal structure of the central domain of Sec16 in complex with Sec13 was solved at 2.7-A...
Topics
- COP-Coated Vesicles
- DNA-Binding Proteins
- Endoplasmic Reticulum
- Membrane Proteins
- Models, Molecular
- Mutation
- Nuclear Pore Complex Proteins
- Protein Structure, Secondary
- Saccharomyces cerevisiae Proteins
- Transcription Factors