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Article

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2010

Eckly A, Rinckel J-Y, Laeuffer P, Cazenave J-P, Lanza F, Gachet C, Léon C

Abstract excerpt

BACKGROUND: Inactivation of the mouse Myh9 gene (Myh9Δ) or its mutation in MYH9-related diseases leads to macrothrombocytopenia. Paradoxically, previous studies using in vitro differentiated megakaryocytes showed an increased capacity for proplatelet formation when myosin was absent or inhibited. METHODS: To explore the origin of the thrombocytopenia induced by myosin deficiency, we studied proplatelet formation...

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Source

Identifiers

PMID: 20695978
DOI: 10.1111/j.1538-7836.2010.04009.x

Genes

MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.PMID 20695978Read ↗

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