Article
Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma.
European journal of cancer (Oxford, England : 1990) - 1 Oct 2010
Perrone Federica, Jocollè Genny, Pennati Marzia, Deraco Marcello, Baratti Dario, Brich Silvia, Orsenigo Marta, Tarantino Eva, De Marco Cinzia, Bertan Claudia, Cabras Antonello, Bertulli Rossella, Pierotti Marco Alessandro, Zaffaroni Nadia, Pilotti Silvana
Abstract excerpt
Our aim was to assess the activation profile of EGFR, PDGFRB and PDGFRA receptor tyrosine kinases (RTK) and their downstream effectors in a series of cryopreserved diffuse malignant peritoneal mesothelioma (DMPM) surgical specimens to discover the targets for drug inhibition. We also made a complementary analysis of the cytotoxic effects of some kinase inhibitors on the proliferation of the human peritoneal...
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