Article
Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors.
Molecular cancer - 19 Feb 2018
Montor Wagner Ricardo, Salas Andrei Ronaldo Oliveira Silva Escartin, Melo Fabiana Henriques Machado de
Abstract excerpt
Searching for targets that allow pharmacological inhibition of cell proliferation in over-proliferative states, such as cancer, leads us to finely understand the complex mechanisms orchestrating the perfect control of mitosis number, frequency and pace as well as the molecular arrangements that induce cells to enter functional quiescence and brings them back to cycling in specific conditions. Although the...
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