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Article

A genetically encoded sensor for H2O2 with expanded dynamic range.

Bioorganic & medicinal chemistry - 1 Feb 2011

Markvicheva Kseniya N, Bilan Dmitry S, Mishina Natalia M, Gorokhovatsky Andrey Yu, Vinokurov Leonid M, Lukyanov Sergey, Belousov Vsevolod V

Abstract excerpt

Hydrogen peroxide is an important second messenger controlling intracellular signaling cascades by selective oxidation of redox active thiolates in proteins. Changes in intracellular [H(2)O(2)] can be tracked in real time using HyPer, a ratiometric genetically encoded fluorescent probe. Although HyPer is sensitive and selective for H(2)O(2) due to the properties of its sensing domain derived from the Escherichia...

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PMID: 20692175
DOI: 10.1016/j.bmc.2010.07.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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