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Article

Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy.

Disease models & mechanisms - 1 Jan 2012

Chevalier-Larsen Erica S, Merry Diane E

Abstract excerpt

Evidence from multiple animal models demonstrates that testosterone plays a crucial role in the progression of symptoms in spinal and bulbar muscular atrophy (SBMA), a condition that results in neurodegeneration and muscle atrophy in affected men. Mice bearing a transgene encoding a human androgen receptor (AR) that contains a stretch of 112 glutamines (expanded polyglutamine tract; AR112Q mice) reproduce several...

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Identifiers

PMID: 21954065
DOI: 10.1242/dmm.007849
PMCID: PMC3255552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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