Article
Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).
The Biochemical journal - 15 Oct 2010
Mouton Véronique, Toussaint Louise, Vertommen Didier, Gueuning Marie-Agnès, Maisin Liliane, Havaux Xavier, Sanchez-Canedo Cossette, Bertrand Luc, Dequiedt Franck, Hemmings Brian A, Hue Louis, Rider Mark H
Abstract excerpt
On the basis of transfection experiments using a dominant-negative approach, our previous studies suggested that PKB (protein kinase B) was not involved in heart PFK-2 (6-phosphofructo2-kinase) activation by insulin. Therefore we first tested whether SGK3 (serum- and glucocorticoid-induced protein kinase 3) might be involved in this effect. Treatment of recombinant heart PFK-2 with [γ-32P]ATP and SGK3 in vitro...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.