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Article

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.

The EMBO journal - 15 Aug 2003

Collins Barry J, Deak Maria, Arthur J Simon C, Armit Laura J, Alessi Dario R

Abstract excerpt

PKB/Akt, S6K, SGK and RSK are mediators of responses triggered by insulin and growth factors and are activated following phosphorylation by 3-phosphoinositide-dependent protein kinase-1 (PDK1). To investigate the importance of a substrate-docking site in the kinase domain of PDK1 termed the 'PIF-pocket', we generated embryonic stem (ES) cells in which both copies of the PDK1 gene were altered by knock-in mutation...

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Source

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Identifiers

PMID: 12912918
DOI: 10.1093/emboj/cdg407
PMCID: PMC175797

Genes

PDK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.PMID 12912918Read ↗

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