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Article

The role of coupled positive feedback in the expression of the SPI1 type three secretion system in Salmonella.

PLoS pathogens - 29 Jul 2010

Saini Supreet, Ellermeier Jeremy R, Slauch James M, Rao Christopher V

Abstract excerpt

Salmonella enterica serovar Typhimurium is a common food-borne pathogen that induces inflammatory diarrhea and invades intestinal epithelial cells using a type three secretion system (T3SS) encoded within Salmonella pathogenicity island 1 (SPI1). The genes encoding the SPI1 T3SS are tightly regulated by a network of interacting transcriptional regulators involving three coupled positive feedback loops. While the...

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Source

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Identifiers

PMID: 20686667
DOI: 10.1371/journal.ppat.1001025
PMCID: PMC2912647

Genes

SPI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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