Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species

Abstract excerpt

The cellular and molecular mechanisms underpinning the unusually high virulence of highly pathogenic avian influenza H5N1 viruses in mammalian species remains unknown.Here, we investigated if the cell tropism of H5N1 virus is a determinant of enhanced virulence in mammalian species.We engineered H5N1 viruses with restricted cell tropism through the exploitation of cell type-specific microRNA expression by...

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