Article
In vivo evidence for transdifferentiation of peripheral neurons.
Development (Cambridge, England) - 1 Sept 2010
Wright Melissa A, Mo Weike, Nicolson Teresa, Ribera Angeles B
Abstract excerpt
It is commonly thought that differentiated neurons do not give rise to new cells, severely limiting the potential for regeneration and repair of the mature nervous system. However, we have identified cells in zebrafish larvae that first differentiate into dorsal root ganglia sensory neurons but later acquire a sympathetic neuron phenotype. These transdifferentiating neurons are present in wild-type zebrafish....
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