Article
WTX mutations can occur both early and late in the pathogenesis of Wilms tumour.
Journal of medical genetics - 1 Nov 2010
Fukuzawa Ryuji, Holman Sarah K, Chow C W, Savarirayan Ravi, Reeve Anthony E, Robertson Stephen P
Abstract excerpt
BACKGROUND: Somatic mutations in the X-linked tumour suppressor gene WTX have been observed in 6- 30% of sporadic cases of Wilms tumour. Germline mutations in the same gene cause the sclerosing skeletal dysplasia, osteopathia striata congenita with cranial sclerosis (OSCS). No evidence points towards a susceptibility to the development of tumours in individuals with OSCS, suggesting that there are unrecognised...
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