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Article

Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour.

Nature genetics - 1 Dec 1993

Park S, Bernard A, Bove K E, Sens D A, Hazen-Martin D J, Garvin A J, Haber D A

Abstract excerpt

Nephrogenic rests consist of foci of primitive renal cells, typically microscopic, that are found within the normal kidney tissue of children with Wilms' tumour. To study the relationship between nephrogenic rests and the associated tumours, we screened these lesions for mutations in the 11p13 Wi...

Topics

Amino Acid Sequence
Child
Child, Preschool
Chromosomes, Human, Pair 13
DNA Mutational Analysis
Female
Genes, Wilms Tumor
Humans
Infant
Kidney
Kidney Neoplasms
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymorphism, Genetic

Wilms Tumor

Source

Identifiers

PMID: 8298644
DOI: 10.1038/ng1293-363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8298644-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour.PMID 8298644Read ↗

Sequential WT1 and CTNNB1 mutations and alterations of beta-catenin localisation in intralobar nephrogenic rests and associated Wilms tumours: two case studies.Semantic proximity Read ↗

The molecular biology of Wilms' tumourSemantic proximity Read ↗

Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes.Semantic proximity Read ↗

Wilms' tumor gene 1: lessons from the interface between kidney development and cancer.Semantic proximity Read ↗

Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice.Semantic proximity Read ↗

Microdissecting the Genetic Events in Nephrogenic Rests and Wilms' Tumor DevelopmentSemantic proximity Read ↗

Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumourSemantic proximity Read ↗

Wilms' tumor and related abnormalities in the fetus and newborn.Semantic proximity Read ↗

Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation.Semantic proximity Read ↗

Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.Semantic proximity Read ↗

Single-nucleotide polymorphism in WT1 gene in a hyperplastic intralobar nephrogenic rest with botryoid protrusion.Semantic proximity Read ↗

Nephroblastoma (Wilms' tumor): a model system of aberrant renal development.Semantic proximity Read ↗

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