Article
Detection of relevant pharmacogenetic information through exome sequencing in oncology.
Pharmacogenomics - 1 Sept 2022
Verdez Simon, Albuisson Juliette, Duffourd Yannis, Boidot Romain, Reda Manon, Thauvin-Robinet Christel, Fumet Jean-David, Ladoire Sylvain, Nambot Sophie, Callier Patrick, Faivre Laurence, Ghiringhelli François, Picard Nicolas
Abstract excerpt
Background: Germline sequencing of individual genomes can detect alleles responsible for adverse drug reactions (ADRs) in relation to chemotherapy, targeted agents, antiemetics or pain treatment. Materials & methods: To evaluate the interest of such pharmacogenetic information, the authors retrospectively analyzed genes known to have an impact on cancer therapy in a cohort of 445 solid cancers patients. Results:...
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