Article
Intermolecular associations determine the dynamics of the circadian KaiABC oscillator.
Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2010
Qin Ximing, Byrne Mark, Mori Tetsuya, Zou Ping, Williams Dewight R, McHaourab Hassane, Johnson Carl Hirschie
Abstract excerpt
Three proteins from cyanobacteria (KaiA, KaiB, and KaiC) can reconstitute circadian oscillations in vitro. At least three molecular properties oscillate during this reaction, namely rhythmic phosphorylation of KaiC, ATP hydrolytic activity of KaiC, and assembly/disassembly of intermolecular compl...
Topics
- Algorithms
- Bacterial Proteins
- Circadian Rhythm
- Circadian Rhythm Signaling Peptides and Proteins
- Electrophoresis, Polyacrylamide Gel
- Fluorescence Polarization
- Kinetics
- Models, Biological
- Models, Chemical
- Molecular Dynamics Simulation
- Mutation
- Peptides
- Phosphorylation
- Protein Binding