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Article

Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation.

Oncogene - 14 Oct 2010

Tsang Y H, Lamb A, Romero-Gallo J, Huang B, Ito K, Peek R M, Ito Y, Chen L F

Abstract excerpt

Chronic infection with cagA-positive Helicobacter pylori is the strongest risk factor for the development of gastric adenocarcinoma. The cagA gene product CagA is injected into gastric epithelial cells and disturbs cellular functions by physically interacting with and deregulating a variety of cellular signaling molecules. RUNX3 is a tumor suppressor in many tissues, and it is frequently inactivated in gastric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20676134
DOI: 10.1038/onc.2010.304
PMCID: PMC2980823

Genes

RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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