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Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma

2 Aug 2010

Abstract excerpt

Hepatocellular carcinoma (HCC) is among the most lethal of human malignancies. During human multistep hepatocarcinogenesis, genomic gain represents an important mechanism in the activation of proto-oncogenes. In many circumstances, activated oncogenes hold clinical implications both as prognostic markers and targets for cancer therapeutics. Gain of chromosome 1q copy is one of the most frequently detected...

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PMID: 20676120
DOI: 10.1038/aps.2010.94

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