Long-term low-dose mutation studies in human cells: metanil yellow and orange II.

doi:10.1016/0027-5107(91)90153-f

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Long-term low-dose mutation studies in human cells: metanil yellow and orange II.

Mutation research - 1 Jul 1991

Rastogi P B, Thilly W G, Shirnamé-Moré L

Abstract excerpt

We tested the mutagenic effects of two commonly used fold colors, metanil yellow and orange II, in AHH-1 human lymphoblast cells. The cell line, which is competent for oxidative metabolism of various chemicals, was exposed to both compounds in high-dose x short-term (3 day) or high-dose x long-term (10-day) and low-dose x long-term (20-day) treatments. Concentrations of metanil yellow and orange II as low as 22...

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Long-term low-dose mutation studies in human cells: metanil yellow and orange II.

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