Long-term low-dose mutation studies in human cells: metanil yellow and orange II.

doi:10.1016/0027-5107(91)90153-f

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Article

Long-term low-dose mutation studies in human cells: metanil yellow and orange II.

Mutation research - 1 Jul 1991

Rastogi P B, Thilly W G, Shirnamé-Moré L

Abstract excerpt

We tested the mutagenic effects of two commonly used fold colors, metanil yellow and orange II, in AHH-1 human lymphoblast cells. The cell line, which is competent for oxidative metabolism of various chemicals, was exposed to both compounds in high-dose x short-term (3 day) or high-dose x long-te...

Topics

Azo Compounds
Biotransformation
Cell Survival
Coloring Agents
Cytochrome P-450 Enzyme System
Dose-Response Relationship, Drug
Humans
Mutagenicity Tests
Mutagens
Mutation
Tumor Cells, Cultured

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