Assessment of the genotoxic effects of methyl chloride in human lymphoblasts.

doi:10.1016/0165-1218(85)90028-x

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Article

Assessment of the genotoxic effects of methyl chloride in human lymphoblasts.

Mutation research - 1 Jan 2000

Fostel J, Allen P F, Bermudez E, Kligerman A D, Wilmer J L, Skopek T R

Abstract excerpt

The activity of methyl chloride was measured in 4 genotoxicity assays. In an established human lymphoblast line, a 3-h treatment with 0-5% methyl chloride resulted in a dose-related increase in mutant fraction at the thymidine kinase locus and induction of sister-chromatid exchange. No increase i...

Topics

DNA
Humans
Lymphocytes
Methyl Chloride
Mutagenicity Tests
Mutation
Salmonella typhimurium
Sister Chromatid Exchange

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