Article
Assessment of the genotoxic effects of methyl chloride in human lymphoblasts.
Mutation research - 1 Jan 2000
Fostel J, Allen P F, Bermudez E, Kligerman A D, Wilmer J L, Skopek T R
Abstract excerpt
The activity of methyl chloride was measured in 4 genotoxicity assays. In an established human lymphoblast line, a 3-h treatment with 0-5% methyl chloride resulted in a dose-related increase in mutant fraction at the thymidine kinase locus and induction of sister-chromatid exchange. No increase in DNA damage, as measured by alkaline elution, was detected in the lymphoblasts at concentrations of methyl chloride...
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