Article
A promoter polymorphism -2122C>T of CHI3L1 is associated with serum low density lipoprotein cholesterol level in Korean subjects.
Clinical biochemistry - 1 Oct 2010
Lee Haeyong, Kang Ryunhwa, Jee Sun Ha, Yoon Yoosik
Abstract excerpt
OBJECTIVES: This study assessed the effects of 10 tagging single nucleotide polymorphisms (SNPs) of the CHI3L1 gene on serum LDL cholesterol levels in 290 Korean subjects. DESIGN AND METHODS: Genotyping analyses of SNPs were conducted by TaqMan® method. The effects of the promoter SNP on mRNA expression and nuclear factor binding were measured by real-time PCR and electrophoretic mobility shift assay,...
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