Article
Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract.
Molecular vision - 1 Jul 2010
Lin Hui-Ju, Huang Yu-Chuen, Lin Jane-Ming, Wu Jer-Yuarn, Chen Liuh-An, Lin Chao-Jen, Tsui Yung-Ping, Chen Chih-Ping, Tsai Fuu-Jen
Abstract excerpt
PURPOSE: Type 2 diabetes (T2D) is highly prevalent worldwide and cataracts are of high incidence in T2D patients. In this study, we identify genetic variants that predispose type 2 diabetes (T2D) patients to cataracts in the Han-Chinese residing in Taiwan. METHODS: We conducted a genome-wide association study with a total of 1,715 cases and 2,000 random controls. In the haplotype study, we defined haplotype 1 (Ht...
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