Article
Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD.
Mucosal immunology - 1 Nov 2010
Viejo-Borbolla A, Martin A P, Muniz L R, Shang L, Marchesi F, Thirunarayanan N, Harpaz N, Garcia R A, Apostolaki M, Furtado G C, Mayer L, Kollias G, Alcami A, Lira S A
Abstract excerpt
Tumor necrosis factor α (TNFα) is a key pathogenic factor in Crohn's disease and rheumatoid arthritis. TNF(ΔARE) mice express high levels of TNFα and present Crohn's-like ileitis and arthritis. Alterations in the chemokine network could underline the TNF-driven ileitis. The aim of this study was to evaluate the role of TNF and chemokines in ileitis using ectromelia virus cytokine response modifier D (CrmD), a...
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