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Article

Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: a case-control study.

Journal of human genetics - 1 Oct 2010

Qin Jianghui, Shi Dongquan, Dai Jin, Zhu Lunqing, Tsezou Aspasia, Jiang Qing

Abstract excerpt

Previous studies have suggested that leptin works as a key regulator in the pathogenesis of osteoarthritis (OA), and genetic factors modulate OA. This study assessed the contribution of leptin gene (LEP) polymorphism(s) to knee OA among Han Chinese. Three tag single-nucleotide polymorphisms (SNPs) covering all those LEP SNPs of which the minor allele frequencies were over 10% were selected. Study subjects (697...

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Source

Identifiers

PMID: 20664554
DOI: 10.1038/jhg.2010.86

Genes

LEP
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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