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Article

Genetic and environmental risk factors in Parkinson's disease.

Clinical neurology and neurosurgery - 1 Mar 1998

Veldman B A, Wijn A M, Knoers N, Praamstra P, Horstink M W

Abstract excerpt

Parkinson's disease (PD) is a multifactorial disorder, caused by a combination of age, genetics and environmental factors. Nigral cells are susceptible to multiple causes of derangement of normal cell function, all of which may contribute to the same Parkinson phenotype. Autosomal dominant alpha-synuclein-gene PD represents one of the pure genetic forms, whereas cases of sporadic PD probably depend more on age...

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PMID: 9637199
DOI: 10.1016/s0303-8467(98)00009-2

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