Article
Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism.
Genes, brain, and behavior - 1 Oct 2010
Correia C T, Coutinho A M, Sequeira A F, Sousa I G, Lourenço Venda L, Almeida J P, Abreu R L, Lobo C, Miguel T S, Conroy J, Cochrane L, Gallagher L, Gill M, Ennis S, Oliveira G G, Vicente A M
Abstract excerpt
The brain-derived neurotrophic factor (BDNF), a neurotrophin fundamental for brain development and function, has previously been implicated in autism. In this study, the levels of BDNF in platelet-rich plasma were compared between autistic and control children, and the role of two genetic factors that might regulate this neurotrophin and contribute to autism etiology, BDNF and NTRK2, was examined. We found that...
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