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Article

Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study.

The Journal of infectious diseases - 1 Sept 2010

Ribaudo Heather J, Liu Huan, Schwab Matthias, Schaeffeler Elke, Eichelbaum Michel, Motsinger-Reif Alison A, Ritchie Marylyn D, Zanger Ulrich M, Acosta Edward P, Morse Gene D, Gulick Roy M, Robbins Gregory K, Clifford David, Haas David W

Abstract excerpt

In AIDS Clinical Trials Group protocols 384, A5095, and A5097s, we characterized relationships between 22 polymorphisms in CYP2B6, ABCB1, and CYP3A5; plasma efavirenz exposure; and/or treatment responses. A stepwise logistic regression procedure selected polymorphisms associated with reduced drug clearance adjusted for body mass index and the composite CYP2B6 516/983 genotype. Relationships between selected...

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Identifiers

PMID: 20662624
DOI: 10.1086/655470
PMCID: PMC2919241

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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